Association of HLA-DQB1*0201 with stiff-man syndrome.

doi:10.1210/jcem.77.6.8263140

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Article

Association of HLA-DQB1*0201 with stiff-man syndrome.

The Journal of clinical endocrinology and metabolism - 1 Dec 1993

Pugliese A, Solimena M, Awdeh Z L, Alper C A, Bugawan T, Erlich H A, De Camilli P, Eisenbarth G S

Abstract excerpt

Stiff-man syndrome (SMS) is a rare disorder of the central nervous system of probable autoimmune origin. Patients with SMS often have other autoimmune diseases, in particular type I (insulin-dependent) diabetes mellitus (IDDM). Approximately 60% of patients with SMS have high titers of autoantibo...

Topics

Adult
Aged
Alleles
Diabetes Mellitus, Type 1
Female
HLA-DQ Antigens
HLA-DQ beta-Chains
Humans
Male
Middle Aged
Stiff-Person Syndrome

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