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Article

The dopamine D2 receptor (DRD2) as a major gene in obesity and height.

Biochemical medicine and metabolic biology - 1 Oct 1993

Comings D E, Flanagan S D, Dietz G, Muhleman D, Knell E, Gysin R

Abstract excerpt

Dopamine plays a major role in the regulation of appetite and growth hormone. Dopaminergic agonists suppress appetite and dopamine D2 receptor antagonists enhance it. We examined the hypothesis that allelic variants of the DRD2 locus may be associated with weight and height. Sarkar and Sommer des...

Topics

Adolescent
Adult
Base Sequence
Body Height
Eating
Genotype
Haplotypes
Humans
Molecular Sequence Data
Obesity
Polymerase Chain Reaction
Polymorphism, Genetic
Receptors, Dopamine D2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8260195
DOI: 10.1006/bmmb.1993.1059

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8260195-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The dopamine D2 receptor (DRD2) as a major gene in obesity and height.PMID 8260195Read ↗

Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention.Semantic proximity Read ↗

Supportive evidence for contribution of the dopamine D2 receptor gene to heritability of stature: linkage and association studies.Semantic proximity Read ↗

No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity.Semantic proximity Read ↗

The Taq IA and Ser311 Cys polymorphisms in the dopamine D2 receptor gene and obesity.Semantic proximity Read ↗

Allelic variations of the D2 dopamine receptor gene in children with idiopathic short stature.Semantic proximity Read ↗

Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric symptoms, and interaction with the dopamine D2 receptor (DRD2) gene.Semantic proximity Read ↗

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Correlation of the Taq1 dopamine D2 receptor gene and percent body fat in obese and screened control subjects: a preliminary report.Semantic proximity Read ↗

DRD2 genetic variation in relation to smoking and obesity in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.Semantic proximity Read ↗

Association of multiple DRD2 polymorphisms with anorexia nervosa.Semantic proximity Read ↗

DRD2 promoter region variation predicts antipsychotic-induced weight gain in first episode schizophreniaSemantic proximity Read ↗

Lack of association between DRD2 and OPRM1 genotypes and adiposity.Semantic proximity Read ↗

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