Article
The dopamine D2 receptor (DRD2) as a major gene in obesity and height.
Biochemical medicine and metabolic biology - 1 Oct 1993
Comings D E, Flanagan S D, Dietz G, Muhleman D, Knell E, Gysin R
Abstract excerpt
Dopamine plays a major role in the regulation of appetite and growth hormone. Dopaminergic agonists suppress appetite and dopamine D2 receptor antagonists enhance it. We examined the hypothesis that allelic variants of the DRD2 locus may be associated with weight and height. Sarkar and Sommer described two DRD2 polymorphisms that could be haplotyped by PCR. For weight, the mean Z score (National Center for Health...
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