Article
Allelic variations of the D2 dopamine receptor gene in children with idiopathic short stature.
Journal of human genetics - 1 Jan 1999
Miyake H, Nagashima K, Onigata K, Nagashima T, Takano Y, Morikawa A
Abstract excerpt
The D2 dopamine receptor (DRD2) plays a major role in growth hormone (GH) secretion. Recent reports indicate that Taq I A DRD2 gene alleles (A1 and A2) are related to the function of DRD2. Idiopathic short stature (ISS) is defined as short stature without accompanying malnutrition, chronic disease, and endocrinological disorders. However, some reports suggest that ISS is associated with a mild disturbance of GH...
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