Article
Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention.
BMC pediatrics - 27 Nov 2013
Roth Christian L, Hinney Anke, Schur Ellen A, Elfers Clinton T, Reinehr Thomas
Abstract excerpt
BACKGROUND: Dopamine receptors are involved in midbrain reward circuit activation. Polymorphisms in two dopamine receptor genes, DRD2 and DRD4, have been associated with altered perception of food reward and weight gain. The objective of this study was to determine whether the same risk alleles were associated with overweight/obesity and with lower reduction of overweight after a 1-year lifestyle intervention....
Topics
- Adolescent
- Adult
- Alleles
- Body Mass Index
- Case-Control Studies
- Child
- Female
- Genotype
- Humans
- Longitudinal Studies
- Male