Article
Low frequency of allelic loss in the cyclin A gene in human hepatocellular carcinomas: a study based on PCR.
Liver - 1 Oct 1993
De Mitri M S, Pisi E, Bréchot C, Paterlini P
Abstract excerpt
The cyclin A gene was first identified at a site of hepatitis B virus DNA integration in a primary liver cancer (PLC). It has now been mapped to 4q27, in the proximity of a chromosomal locus (4q32) which is frequently rearranged and deleted in PLC. We took advantage of the TaqI polymorphism recently described in the cyclin A gene to search for allelic loss in this gene by means of PCR. Tumorous and non-tumorous...
Topics
- Alleles
- Carcinoma, Hepatocellular
- Cyclins
- Humans
- Liver Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Genetic