Article
After BRCA1 and BRCA2-what next? Multifactorial segregation analyses of three-generation, population-based Australian families affected by female breast cancer.
American journal of human genetics - 1 Feb 2001
Cui J, Antoniou A C, Dite G S, Southey M C, Venter D J, Easton D F, Giles G G, McCredie M R, Hopper J L
Abstract excerpt
Mutations in BRCA1 and BRCA2 that cause a dominantly inherited high risk of female breast cancer seem to explain only a small proportion of the aggregation of the disease. To study the possible additional genetic components, we conducted single-locus and two-locus segregation analyses, with and without a polygenic background, using three-generation families ascertained through 858 women with breast cancer...
Topics
- Age Factors
- Age of Onset
- Australia
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Cohort Studies
- Family Health
- Female
- Heterozygote
- Humans
- Male
- Models, Genetic
- Molecular Sequence Data