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Article

Neurological manifestations of knockout mice with beta-galactosidase deficiency.

Brain & development - 1 Jan 1997

Matsuda J, Suzuki O, Oshima A, Ogura A, Naiki M, Suzuki Y

Abstract excerpt

We succeeded in producing the beta-galactosidase-deficient knockout mouse by gene targeting in embryonic stem cells. The mutant mice developed progressive spastic diplegia within a few months after birth, and died of emaciation at 7-10 months of age. This is an authentic murine model of human GMI-gangliosidosis, and is useful for studies of its pathogenesis and treatment.

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Identifiers

PMID: 9071485
DOI: 10.1016/s0387-7604(96)00077-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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