Neurological manifestations of knockout mice with beta-galactosidase deficiency.

doi:10.1016/s0387-7604(96)00077-0

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Article

Neurological manifestations of knockout mice with beta-galactosidase deficiency.

Brain & development - 1 Jan 1997

Matsuda J, Suzuki O, Oshima A, Ogura A, Naiki M, Suzuki Y

Abstract excerpt

We succeeded in producing the beta-galactosidase-deficient knockout mouse by gene targeting in embryonic stem cells. The mutant mice developed progressive spastic diplegia within a few months after birth, and died of emaciation at 7-10 months of age. This is an authentic murine model of human GMI...

Topics

Animals
Disease Models, Animal
Female
Gangliosidosis, GM1
Genotype
Homozygote
Male
Mice
Mice, Knockout
Mice, Neurologic Mutants
Mutagenesis
beta-Galactosidase

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