Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression.

doi:10.1016/0161-5890(93)90450-p

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Article

Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression.

Molecular immunology - 1 Dec 1993

Horiuchi T, Kim S, Matsumoto M, Watanabe I, Fujita S, Volanakis J E

Abstract excerpt

A full-length cDNA clone, BHL4-1, encoding factor B was isolated from a human liver cDNA library and sequenced in its entirety. It consists of 2388 bp which include a 5'-untranslated region of 40 bp, a single open reading frame, 2292 bp in length, and a 3'-untranslated region of 56 bp followed by a poly-A tail. The deduced amino acid sequence comprises 25 residues of a putative leader peptide and 739 residues of...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Cell Line
Cloning, Molecular
Complement Activation
Complement C2
Complement C3-C5 Convertases
Complement Factor B
DNA, Complementary
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Liver

Molecular Sequence Data

Mutagenesis, Site-Directed

Phenotype

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 8247029
DOI: 10.1016/0161-5890(93)90450-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8247029-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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