Effect of protein C gene mutation on coagulation and inflammation in hemorrhagic shock.

doi:10.1016/j.jss.2011.06.055

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Article

Effect of protein C gene mutation on coagulation and inflammation in hemorrhagic shock.

The Journal of surgical research - 1 Jun 2012

Burruss Sigrid, Andakyan Arthur, Romanov Sergei, Semiletova Natalya, Cryer Henry

Abstract excerpt

INTRODUCTION: Trauma patients are at high risk of complications and death from coagulopathy and inflammatory organ failure. Recent evidence implicates protein C (PC) as a key mediator of this process. We hypothesized that a mutation in the PC gene would ameliorate the inflammatory and coagulopathic response to hemorrhagic shock (HS) and resuscitation. METHODS: FHH wild type and PC mutant rats underwent controlled...

Topics

Animals
Biomarkers
Blood Coagulation
Disease Models, Animal
Fluid Therapy
Inflammation
Isotonic Solutions
Mutation
Protein C
Rats
Resuscitation
Ringer's Lactate
Shock, Hemorrhagic

Source

Open in PubMed

Identifiers

PMID: 21962741
DOI: 10.1016/j.jss.2011.06.055

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