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Article

Functional identification of factor VIII B domain regions in hepatocyte cells.

Biochemical and biophysical research communications - 4 Jun 2020

Jun Zhang, Ming-Ming Lin, Qian-Qing Zhang, Yun-Hong Wang, Chong-Yang Zhu, Xin Li

Abstract excerpt

Factor VIII (FVIII) functions as a cofactor within the intrinsic pathway of blood coagulation in process of FX activation by FIXa, for which deficiency results in the bleeding disorder hemophilia A. The gene of FVIII contains 26 exons that code for a 19 amino acid signal peptide and a 2332 amino acid polypeptide with a domain structure designated A1-A2-B-A3-C1-C2, of which the A domains are homologous with each...

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PMID: 32248973
DOI: 10.1016/j.bbrc.2020.03.132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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