Article
Expression and function of the cytoplasmic variants of the integrin alpha 6 subunit in transfected K562 cells. Activation-dependent adhesion and interaction with isoforms of laminin.
The Journal of biological chemistry - 5 Dec 1993
Delwel G O, Hogervorst F, Kuikman I, Paulsson M, Timpl R, Sonnenberg A
Abstract excerpt
Two variants of the cytoplasmic domain of the integrin alpha 6 subunit have been identified (alpha 6A and alpha 6B). To determine the role of each variant in mediating cell adhesion to laminin, we have independently expressed the alpha 6A and alpha 6B subunits in K562 cells. Both variants associa...
Topics
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Line
- Cell Membrane
- Cytoplasm
- Gene Expression
- Genetic Variation
- Humans
- Integrins
- Kinetics
- Laminin
- Leukemia, Erythroblastic, Acute