Article
Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin.
The Journal of experimental medicine - 1 Aug 1993
Kassner P D, Hemler M E
Abstract excerpt
Integrins can exist in a range of functional states, depending on the cell type and its state of activation. Although the mechanism that controls activity is unknown, it has been suggested that for some integrins, alpha chain cytoplasmic domains may exert either a negative effect or no effect on...
Topics
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Line
- Cytoplasm
- Fibronectins
- Intercellular Signaling Peptides and Proteins
- Mutation
- Peptide Fragments
- Peptides
- Receptors, Very Late Antigen
- Recombinant Fusion Proteins
- Sequence Deletion
- Tetradecanoylphorbol Acetate
- Vascular Cell Adhesion Molecule-1