Article
Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line.
The Journal of biological chemistry - 25 May 1993
Shaw L M, Lotz M M, Mercurio A M
Abstract excerpt
Leukocytes use the alpha 6 beta 1 integrin to adhere to laminin based on mAb inhibition and affinity chromatography studies. This adhesion requires leukocyte stimulation with either PMA or specific cytokines, a process that has been termed "inside-out" integrin signaling. In the present study, th...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Cell Adhesion
- Cell Line
- Chickens
- Cloning, Molecular
- DNA
- Female
- Genetic Variation
- Humans
- Integrins
- Laminin
- Macrophage Activation
- Macrophages
- Mice
- Mice, Inbred C57BL