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The Molecular Biology of Leukocyte Chemoattractant Receptors

1 Apr 1994

Abstract excerpt

Leukocytes migrate from the blood to sites of inflammation in response to locally produced chemoattractants that activate specific cell surface receptors. The primary structures of leukocyte receptors for N-formyl peptides, C5a, platelet-activating factor, and 8 of the 18 known human chemokines (interleukin-8 and related molecules) have been deduced from cloned cDNAs. All of these are seven-transmembrane-domain...

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PMID: 8011292
DOI: 10.1146/annurev.iy.12.040194.003113

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