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Article

Rifampicin resistance of Mu lysogenic strains by rpoB mutations.

Biological chemistry Hoppe-Seyler - 1 Aug 1993

Kirschbaum T M, Götte R F

Abstract excerpt

The resistance of Escherichia coli against the antibiotic rifampicin is caused by mutations in the rpoB gene which alter the structure of the beta subunit of the DNA-dependent RNA polymerase. By insertion-mutagenesis with bacteriophage Mu rifampicin-resistant mutants that were believed to have a sensitive RNA polymerase had been generated. For closer analysis of this putative rpoB-independent mechanism of...

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Identifiers

PMID: 8240720
DOI: 10.1515/bchm3.1993.374.7-12.657

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