Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rifampicin resistance of Mu lysogenic strains by rpoB mutations.

Biological chemistry Hoppe-Seyler - 1 Aug 1993

Kirschbaum T M, Götte R F

Abstract excerpt

The resistance of Escherichia coli against the antibiotic rifampicin is caused by mutations in the rpoB gene which alter the structure of the beta subunit of the DNA-dependent RNA polymerase. By insertion-mutagenesis with bacteriophage Mu rifampicin-resistant mutants that were believed to have a sensitive RNA polymerase had been generated. For closer analysis of this putative rpoB-independent mechanism of...

Topics

Bacteriophage mu
Base Sequence
DNA-Directed RNA Polymerases
Drug Resistance, Microbial
Escherichia coli
Genes, Bacterial
Lipopolysaccharides
Lysogeny
Microbial Sensitivity Tests
Molecular Sequence Data
Mutagenesis, Insertional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Rifampin

Sensitivity and Specificity

Source

Identifiers

PMID: 8240720
DOI: 10.1515/bchm3.1993.374.7-12.657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8240720-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rifampicin resistance of Mu lysogenic strains by rpoB mutations.PMID 8240720Read ↗

Rifampicin-resistant meningococci causing invasive disease: detection of point mutations in the rpoB gene and molecular characterization of the strains.Semantic proximity Read ↗

Rifampin: mechanisms of action and resistance.Semantic proximity Read ↗

Mutations in <i>rpoB</i> that confer rifampicin resistance can alter levels of peptidoglycan precursors and affect β-lactam susceptibilitySemantic proximity Read ↗

Molecular characterization of Rif(r) mutations in Pseudomonas aeruginosa and Pseudomonas putida.Semantic proximity Read ↗

Sequencing of the rpoB gene in Legionella pneumophila and characterization of mutations associated with rifampin resistance in the Legionellaceae.Semantic proximity Read ↗

Description of new mutations in the rpoB gene in rifampicin-resistant Neisseria meningitidis selected in vitro in a stepwise manner.Semantic proximity Read ↗

Novel rpoB mutations conferring rifampin resistance on Bacillus subtilis: global effects on growth, competence, sporulation, and germination.Semantic proximity Read ↗

Rifampicin-resistant RpoB S522L Vibrio vulnificus exhibits disturbed stress response and hypervirulence traits.Semantic proximity Read ↗

Identification of a single base change in ribosomal RNA leading to erythromycin resistance.Semantic proximity Read ↗

Molecular basis of rifampin resistance in Mycobacterium leprae.Semantic proximity Read ↗

Isolation of rifampin-resistant mutants of Listeria monocytogenes and their characterization by rpoB gene sequencing, temperature sensitivity for growth, and interaction with an epithelial cell line.Semantic proximity Read ↗

Toxic effects of high levels of ppGpp in Escherichia coli are relieved by rpoB mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.