Rifampicin-resistant RpoB S522L Vibrio vulnificus exhibits disturbed stress response and hypervirulence traits.

doi:10.1002/mbo3.1379

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Article

Rifampicin-resistant RpoB S522L Vibrio vulnificus exhibits disturbed stress response and hypervirulence traits.

MicrobiologyOpen - 1 Oct 2023

Cutugno Laura, O'Byrne Conor, Pané-Farré Jan, Boyd Aoife

Abstract excerpt

Rifampicin resistance, which is genetically linked to mutations in the RNA polymerase β-subunit gene rpoB, has a global impact on bacterial transcription and cell physiology. Previously, we identified a substitution of serine 522 in RpoB (i.e., RpoBS522L ) conferring rifampicin resistance to Vibrio vulnificus, a human food-borne and wound-infecting pathogen associated with a high mortality rate. Transcriptional...

Topics

Humans
Rifampin
Vibrio vulnificus
Bacterial Proteins
Mutation
Virulence
DNA-Directed RNA Polymerases

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PMID: 37877661
DOI: 10.1002/mbo3.1379
PMCID: PMC10493491

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