Article
Rifampicin-resistant meningococci causing invasive disease: detection of point mutations in the rpoB gene and molecular characterization of the strains.
The Journal of antimicrobial chemotherapy - 1 Feb 2001
Stefanelli P, Fazio C, La Rosa G, Marianelli C, Muscillo M, Mastrantonio P
Abstract excerpt
Mutations in the rpoB gene affecting two amino acids were found in eight rifampicin-resistant Neisseria meningitidis group B and C strains isolated in Italy. The Asp542-->Val substitution, documented for the first time in N. meningitidis, was found in four of the isolates; the His552-->Tyr or Asn substitution in the other four resistant strains. Mutations in the mtr gene did not seem to be involved in the...
Topics
- Antibiotics, Antitubercular
- DNA Fingerprinting
- DNA-Directed RNA Polymerases
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- France
- Genotype
- Humans
- Meningococcal Infections
- Molecular Sequence Data
- Mutation
- Neisseria meningitidis
- Phenotype