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Article

Onset and progression of pathological lesions in transforming growth factor-beta 1-deficient mice.

The American journal of pathology - 1 Jan 1995

Boivin G P, O'Toole B A, Orsmby I E, Diebold R J, Eis M J, Doetschman T, Kier A B

Abstract excerpt

Null-mutant (knockout) mice were obtained through disruption of the sixth exon of the endogenous transforming growth factor-beta 1 allele in murine embryonic stem cells via homologous recombination. Mice lacking transforming growth factor-beta 1 (mutants) were born grossly indistinguishable from wild-type littermates. With time, mutant mice exhibited a wasting phenotype that manifested itself in severe weight...

Topics

Animals
Base Sequence
Disease Models, Animal
Flow Cytometry
Genotype
Inflammation
Mice
Mice, Knockout
Molecular Sequence Data
Transforming Growth Factor beta
Weight Gain

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Identifiers

PMID: 7856734
PMCID: PMC1870775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7856734-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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