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Article

Onset and progression of pathological lesions in transforming growth factor-beta 1-deficient mice.

The American journal of pathology - 1 Jan 1995

Boivin G P, O'Toole B A, Orsmby I E, Diebold R J, Eis M J, Doetschman T, Kier A B

Abstract excerpt

Null-mutant (knockout) mice were obtained through disruption of the sixth exon of the endogenous transforming growth factor-beta 1 allele in murine embryonic stem cells via homologous recombination. Mice lacking transforming growth factor-beta 1 (mutants) were born grossly indistinguishable from wild-type littermates. With time, mutant mice exhibited a wasting phenotype that manifested itself in severe weight...

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Identifiers

PMID: 7856734
PMCID: PMC1870775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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