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Article

Cpf1 protein induced bending of yeast centromere DNA element I.

Nucleic acids research - 11 Oct 1993

Niedenthal R K, Sen-Gupta M, Wilmen A, Hegemann J H

Abstract excerpt

The centromere complex is a multicomponent structure essential for faithful chromosome transmission. Here we show that the S. cerevisiae centromere protein Cpf1 bends centromere DNA element I (CDEI) with the bend angle ranging from 66 degrees to 71 degrees. CDEI DNA sequences that carry point mutations which lead to reduced Cpf1 binding affinity and in vivo centromere activity are still able to show bending. The...

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Identifiers

PMID: 8233820
DOI: 10.1093/nar/21.20.4726
PMCID: PMC331497

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