Heavy chain variable region gene utilization in human antibodies.

doi:10.3109/08830189009056731

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Article

Heavy chain variable region gene utilization in human antibodies.

International reviews of immunology - 1 Jan 1990

Pascual V, Andris J, Capra J D

Abstract excerpt

We have sequenced by the polymerase chain reaction the heavy chain variable regions of over thirty human antibodies of defined specificity. The distribution of VH families in this group of antibodies is disproportionately skewed toward the recently discovered VH gene families. Within a family, th...

Topics

Autoantibodies
Gene Expression
Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Isotypes
Immunoglobulin J-Chains
Immunoglobulin Variable Region
Multigene Family
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic

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