Article
Inhibition of AIDS-associated Kaposi's sarcoma cell growth by DAB389-interleukin 6.
AIDS research and human retroviruses - 1 Aug 1994
Masood R, Lunardi-Iskandar Y, Jean L F, Murphy J R, Waters C, Gallo R C, Gill P
Abstract excerpt
Acquired immune deficiency syndrome-associated Kaposi's sarcoma (AIDS-KS)-derived spindle cells produce and use interleukin 6 (IL-6) among several other cytokines as a growth factor. In this study we show that AIDS-KS cells express approximately 1100 high-affinity IL-6 receptors (IL-6R) per cell with a dissociation constant (Kd) of 110 pM. Furthermore, AIDS-KS cells express the IL-6R alpha subunit, detected as a...
Topics
- Acquired Immunodeficiency Syndrome
- Base Sequence
- Cell Division
- Cell Survival
- Diphtheria Toxin
- Gene Expression Regulation, Neoplastic
- Hematopoietic Stem Cells
- Humans
- Interleukin-6
- Kinetics
- Molecular Sequence Data