Cytotoxicity of folate-Pseudomonas exotoxin conjugates toward tumor cells. Contribution of translocation domain.

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Article

Cytotoxicity of folate-Pseudomonas exotoxin conjugates toward tumor cells. Contribution of translocation domain.

The Journal of biological chemistry - 25 Nov 1993

Leamon C P, Pastan I, Low P S

Abstract excerpt

Folate-protein conjugates can be nondestructively delivered into a cell's cytoplasm via folate receptor-mediated endocytosis if (i) the target cells express a folate-binding protein, and (ii) if the folate is linked to its attached protein at a site that does not interfere with receptor recogniti...

Topics

ADP Ribose Transferases
Animals
Bacterial Toxins
Biological Transport
Cell Survival
Cells, Cultured
Cytotoxins
Exotoxins
Folic Acid
Humans
Kinetics
Mutation
N-Glycosyl Hydrolases
Plant Proteins
Protein Biosynthesis
Ribosome Inactivating Proteins, Type 2
Virulence Factors
Pseudomonas aeruginosa Exotoxin A

Source

Open in PubMed

Identifiers

PMID: 8227046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8227046-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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