Article
tRNA modification activity is necessary for Tet(M)-mediated tetracycline resistance.
Journal of bacteriology - 1 Nov 1993
Burdett V
Abstract excerpt
Tet(M) protein interacts with the protein biosynthetic machinery to render this process resistant to the tetracycline in vivo and in vitro (V. Burdett, J. Biol. Chem. 266:2872-2877, 1991). To understand this process more completely, a mutant of Escherichia coli which is altered in the ability of Tet(M) to confer resistance has been identified. This mutation maps to miaA and displays phenotypes characteristic of...
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