tRNA modification activity is necessary for Tet(M)-mediated tetracycline resistance.

doi:10.1128/jb.175.22.7209-7215.1993

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Article

tRNA modification activity is necessary for Tet(M)-mediated tetracycline resistance.

Journal of bacteriology - 1 Nov 1993

Burdett V

Abstract excerpt

Tet(M) protein interacts with the protein biosynthetic machinery to render this process resistant to the tetracycline in vivo and in vitro (V. Burdett, J. Biol. Chem. 266:2872-2877, 1991). To understand this process more completely, a mutant of Escherichia coli which is altered in the ability of Tet(M) to confer resistance has been identified. This mutation maps to miaA and displays phenotypes characteristic of...

Topics

Bacterial Proteins
DNA Probes
DNA Transposable Elements
Escherichia coli
Ethyl Methanesulfonate
Genes, Bacterial
Kinetics
Microbial Sensitivity Tests
Mutagenesis
Mutagenesis, Insertional
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

R Factors

RNA, Transfer

Restriction Mapping

Tetracycline

Tetracycline Resistance

Source

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Identifiers

PMID: 8226667
DOI: 10.1128/jb.175.22.7209-7215.1993
PMCID: PMC206862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8226667-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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