Article
Protective immunity is induced by a Borrelia burgdorferi mutant that lacks OspA and OspB.
Infection and immunity - 1 Dec 1993
Hughes C A, Engstrom S M, Coleman L A, Kodner C B, Johnson R C
Abstract excerpt
A mutant of virulent Borrelia burgdorferi 297 was apparently selected for by long-term storage at 5 degrees C. This mutant was found to lack the plasmid which encodes outer surface protein A (OspA) and OspB. In addition to the loss of the OspA and OspB proteins, the mutant lacked two lipoproteins...
Topics
- Animals
- Antigens, Bacterial
- Antigens, Surface
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Base Sequence
- Borrelia burgdorferi Group
- Cricetinae
- DNA, Bacterial
- Lipoproteins
- Lyme Disease
- Male