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Article

Protective immunity is induced by a Borrelia burgdorferi mutant that lacks OspA and OspB.

Infection and immunity - 1 Dec 1993

Hughes C A, Engstrom S M, Coleman L A, Kodner C B, Johnson R C

Abstract excerpt

A mutant of virulent Borrelia burgdorferi 297 was apparently selected for by long-term storage at 5 degrees C. This mutant was found to lack the plasmid which encodes outer surface protein A (OspA) and OspB. In addition to the loss of the OspA and OspB proteins, the mutant lacked two lipoproteins, of 20 and 7.5 kDa, that were observed in the wild type. Since the mutant was not recovered from the tissues or blood...

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Identifiers

PMID: 8225588
DOI: 10.1128/iai.61.12.5115-5122.1993
PMCID: PMC281290

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