Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigating the potential role of non-vls genes on linear plasmid 28-1 in virulence and persistence by Borrelia burgdorferi.

BMC microbiology - 8 Aug 2016

Magunda Petronella R Hove, Bankhead Troy

Abstract excerpt

BACKGROUND: The lp28-1 plasmid is required for persistent infection by the Lyme disease spirochete, Borrelia burgdorferi. Mutational studies on this plasmid have shown that the vls locus is important for antigenic variation of the VlsE lipoprotein that leads to immune evasion and persistence. However, it is still unknown whether the vls system is the only genetic locus on this plasmid necessary for long-term...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Bacterial
Share to Bacterial Outer Membrane Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Borrelia burgdorferi

Share to Down-Regulation

Share to Immune Evasion

Share to Lipoproteins

Share to Lyme Disease

Share to Mice, Inbred C3H

Source

Open in PubMed Open full text

Identifiers

PMID: 27502325
DOI: 10.1186/s12866-016-0806-4
PMCID: PMC4977671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the potential role of non-vls genes on linear plasmid 28-1 in virulence and persistence by Borrelia burgdorferi.PMID 27502325Read ↗

The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogensSemantic proximity Read ↗

Effects of vlsE complementation on the infectivity of Borrelia burgdorferi lacking the linear plasmid lp28-1.Semantic proximity Read ↗

Association of linear plasmid 28-1 with an arthritic phenotype of Borrelia burgdorferi.Semantic proximity Read ↗

bptA ( bbe16 ) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi , in its natural tick vectorSemantic proximity Read ↗

Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes.Semantic proximity Read ↗

Breaking a barrier: In trans vlsE recombination and genetic manipulation of the native vlsE gene of the Lyme disease pathogenSemantic proximity Read ↗

A small intergenic region of lp17 is required for evasion of adaptive immunity and induction of pathology by the Lyme disease spirocheteSemantic proximity Read ↗

vls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework Heterogeneity.Semantic proximity Read ↗

Experimental assessment of the roles of linear plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the infectious cycle.Semantic proximity Read ↗

Multipartite Genome of Lyme Disease Borrelia: Structure, Variation and ProphagesSemantic proximity Read ↗

Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivoSemantic proximity Read ↗

Altered Murine Tissue Colonization by Borrelia burgdorferi following Targeted Deletion of Linear Plasmid 17-Carried GenesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.