Article
Persistence of anti-donor allohelper T cells after neonatal induction of allotolerance in mice.
European journal of immunology - 1 Aug 1990
Abramowicz D, Vandervorst P, Bruyns C, Doutrelepont J M, Vandenabeele P, Goldman M
Abstract excerpt
BALB/c mice rendered tolerant to A/J alloantigens by neonatal injection of 10(8) (A/J X BALB/c)F1 spleen cells develop an autoimmune disease associated with a polyclonal activation of donor B cells. To study the mechanisms leading to donor B cell activation in tolerant mice, we prepared mixed lymphocyte cultures (MLC) between splenic T cells from neonatally injected mice and donor-type (A/J X BALB/c)F1 or...
Topics
- Animals
- Antibodies, Monoclonal
- B-Lymphocytes
- Enzyme-Linked Immunosorbent Assay
- Immune Tolerance
- Immunization, Passive
- Immunoglobulin M
- Interleukin-2
- Interleukin-4
- Isoantigens
- Lymphocyte Activation