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Article

Development and tolerization of hyperacute rejection in a transgenic mouse graft versus host model.

Transplantation - 15 Aug 2012

Oh Soyoung, Schwartz Ronald H, Singh Nevil J

Abstract excerpt

BACKGROUND: The hyperacute rejection mediated by preexisting antibodies is a major impediment to the success of transplants across allogeneic and xenogeneic barriers. We report a new mouse model that allows us to not only monitor the sensitization of B cells mediating the hyperacute response but also validate therapeutic strategies for tolerizing them. MODEL: The new model system uses 5C.C7,RAG2 T-cell receptor...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22797707
DOI: 10.1097/TP.0b013e31825ccb91
PMCID: PMC3414651

Genes

RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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