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Article

In vitro genetic analysis of the structural features of the pre-tRNA required for determination of the 3' splice site in the intron excision reaction.

The EMBO journal - 1 Dec 1993

Bufardeci E, Fabbri S, Baldi M I, Mattoccia E, Tocchini-Valentini G P

Abstract excerpt

During processing of intron-containing pre-tRNAs, the Xenopus laevis splicing endonuclease binds the precursor and cleaves it at both the 5' and 3' splice sites. In vitro selection was used to determine structural features characteristic of precursor tRNA molecules that are active in this reaction. We performed two types of selection, one for molecules that are not cut, the other for molecules that are cut at...

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Identifiers

PMID: 8223479
DOI: 10.1002/j.1460-2075.1993.tb06158.x
PMCID: PMC413913

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Source receipt: pubmed, retrieved 7 Sept 2026.

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