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Article

Splice junction mutations in a yeast tRNA gene which alter the rate and precision of processing.

Biochimica et biophysica acta - 6 Apr 1990

Chambers J, Raymond G J, Kim D, Raymond K C, Nelson C, Clark S, Johnson J D

Abstract excerpt

We have introduced mutations into a tRNALeu3 gene which alter the intron boundaries and examined their effects on RNA splicing. Our results show that the 5'-proximal splice junction is not specified by the position of an adjacent base-paired stem present in all naturally occurring tRNA precursors. Also, efficient cleavage of 5'-splice junctions unique to these mutants, -CpU-, -UpA- and -UpG-, indicates the purine...

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Identifiers

PMID: 2182122
DOI: 10.1016/0167-4781(90)90051-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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