Article
The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication.
The EMBO journal - 1 Dec 1993
Collins K L, Russo A A, Tseng B Y, Kelly T J
Abstract excerpt
DNA polymerase alpha is the only enzyme in eukaryotic cells capable of starting DNA chains de novo and is required for the initiation of SV40 DNA replication in vitro. We have cloned the 70 kDa subunit of human DNA polymerase alpha (hereafter referred to as the B subunit) and expressed it as a fu...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Polyomavirus Transforming
- Base Sequence
- Cloning, Molecular
- DNA
- DNA Polymerase II
- DNA Replication
- DNA, Viral
- Escherichia coli
- Humans
- Mice
- Molecular Sequence Data
- Mutation