Article
The carboxyl terminal sequence of nucleolar protein B23.1 is important in its DNA polymerase alpha-stimulatory activity.
Journal of biochemistry - 1 Aug 2001
Umekawa H, Sato K, Takemura M, Watanabe Y, Usui S, Takahashi T, Yoshida S, Olson M O, Furuichi Y
Abstract excerpt
The protein B23 is a major nucleolar phosphoprotein comprising two isoforms, B23.1 and B23.2, which differ only in their carboxyl-terminal short sequences, the N-terminal 255 residues being identical in both forms. Both B23.1 and B23.2 stimulated immunoaffinity-purified calf thymus DNA polymerase alpha in a dose-dependent manner. The stimulatory effect of protein B23.1, the longer isoform, was found to be 2-fold...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.