Protein-protein interactions in gene regulation: the cAMP-CRP complex sets the specificity of a second DNA-binding protein, the CytR repressor.

doi:10.1016/0092-8674(93)90389-8

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Article

Protein-protein interactions in gene regulation: the cAMP-CRP complex sets the specificity of a second DNA-binding protein, the CytR repressor.

Cell - 5 Nov 1993

Søgaard-Andersen L, Valentin-Hansen P

Abstract excerpt

Maximal repression by the CytR protein depends on the formation of nucleoprotein complexes in which CytR interacts with DNA and with cAMP-cAMP receptor protein (CRP). Here we demonstrate that CytR regulates transcription from deoP2 promoters in which the entire CytR recognition sequence has been...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Chromosome Mapping
Cyclic AMP
Enzyme Repression
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Genes, Reporter
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Operator Regions, Genetic

Promoter Regions, Genetic

Receptors, Cyclic AMP

Recombinant Fusion Proteins

Repressor Proteins

Source

Open in PubMed

Identifiers

PMID: 8221894
DOI: 10.1016/0092-8674(93)90389-8

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8221894-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Protein-protein interactions in gene regulation: the cAMP-CRP complex sets the specificity of a second DNA-binding protein, the CytR repressor.PMID 8221894Read ↗

Tandem DNA-bound cAMP-CRP complexes are required for transcriptional repression of the deoP2 promoter by the CytR repressor in Escherichia coli.Semantic proximity Read ↗

A novel function of the cAMP-CRP complex in Escherichia coli: cAMP-CRP functions as an adaptor for the CytR repressor in the deo operon.Semantic proximity Read ↗

Protein-protein communication: structural model of the repression complex formed by CytR and the global regulator CRP.Semantic proximity Read ↗

The CytR repressor antagonizes cyclic AMP-cyclic AMP receptor protein activation of the deoCp2 promoter of Escherichia coli K-12.Semantic proximity Read ↗

Identification of the nucleotide sequence recognized by the cAMP-CRP dependent CytR repressor protein in the deoP2 promoter in E. coli.Semantic proximity Read ↗

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Transcriptional regulation of the cytR repressor gene of Escherichia coli: autoregulation and positive control by the cAMP/CAP complex.Semantic proximity Read ↗

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Dissection of a surface-exposed portion of the cAMP-CRP complex that mediates transcription activation and repression.Semantic proximity Read ↗

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