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Article

Allosteric mechanism of induction of CytR-regulated gene expression. Cytr repressor-cytidine interaction.

The Journal of biological chemistry - 4 Jul 1997

Barbier C S, Short S A, Senear D F

Abstract excerpt

Transcription from cistrons of the Escherichia coli CytR regulon is activated by E. coli cAMP receptor protein (CRP) and repressed by a multiprotein complex composed of CRP and CytR. De-repression results when CytR binds cytidine. CytR is a homodimer and a LacI family member. A central question for all LacI family proteins concerns the allosteric mechanism that couples ligand binding to the protein-DNA and...

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Source

Identifiers

PMID: 9202008
DOI: 10.1074/jbc.272.27.16962

Genes

CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Allosteric mechanism of induction of CytR-regulated gene expression. Cytr repressor-cytidine interaction.PMID 9202008Read ↗

Transcriptional regulation of the cytR repressor gene of Escherichia coli: autoregulation and positive control by the cAMP/CAP complex.Semantic proximity Read ↗

Protein-protein communication: structural model of the repression complex formed by CytR and the global regulator CRP.Semantic proximity Read ↗

Protein-protein interactions in gene regulation: the cAMP-CRP complex sets the specificity of a second DNA-binding protein, the CytR repressor.Semantic proximity Read ↗

Identification of the nucleotide sequence recognized by the cAMP-CRP dependent CytR repressor protein in the deoP2 promoter in E. coli.Semantic proximity Read ↗

The CytR repressor antagonizes cyclic AMP-cyclic AMP receptor protein activation of the deoCp2 promoter of Escherichia coli K-12.Semantic proximity Read ↗

Tandem DNA-bound cAMP-CRP complexes are required for transcriptional repression of the deoP2 promoter by the CytR repressor in Escherichia coli.Semantic proximity Read ↗

Characterization of cytR mutations that influence oligomerization of mutant repressor subunits.Semantic proximity Read ↗

A novel function of the cAMP-CRP complex in Escherichia coli: cAMP-CRP functions as an adaptor for the CytR repressor in the deo operon.Semantic proximity Read ↗

Genetic strategy for analyzing specificity of dimer formation: Escherichia coli cyclic AMP receptor protein mutant altered in its dimerization specificity.Semantic proximity Read ↗

Dissection of a surface-exposed portion of the cAMP-CRP complex that mediates transcription activation and repression.Semantic proximity Read ↗

Vibrio cholerae CytR is a repressor of biofilm development.Semantic proximity Read ↗

Absolute requirement of cyclic nucleotide in the activation of the G141Q mutant cAMP receptor protein from Escherichia coli.Semantic proximity Read ↗

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