Article
Allosteric mechanism of induction of CytR-regulated gene expression. Cytr repressor-cytidine interaction.
The Journal of biological chemistry - 4 Jul 1997
Barbier C S, Short S A, Senear D F
Abstract excerpt
Transcription from cistrons of the Escherichia coli CytR regulon is activated by E. coli cAMP receptor protein (CRP) and repressed by a multiprotein complex composed of CRP and CytR. De-repression results when CytR binds cytidine. CytR is a homodimer and a LacI family member. A central question f...
Topics
- Allosteric Regulation
- Bacterial Proteins
- Cytidine
- Dimerization
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation
- Kinetics
- Models, Chemical
- Models, Molecular
- Mutation
- Operon
- Phenotype
- Repressor Proteins
- Transcription, Genetic