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Article

The cyclic AMP (cAMP)-cAMP receptor protein complex functions both as an activator and as a corepressor at the tsx-p2 promoter of Escherichia coli K-12.

Journal of bacteriology - 1 Sept 1991

Gerlach P, Søgaard-Andersen L, Pedersen H, Martinussen J, Valentin-Hansen P, Bremer E

Abstract excerpt

The tsx-p2 promoter is one of at least seven Escherichia coli promoters that are activated by the cyclic AMP (cAMP)-cAMP receptor protein (CRP) complex and negatively regulated by the CytR repressor. DNase I footprinting assays were used to study the interactions of these regulatory proteins with the tsx-p2 promoter region and to characterize tsx-p2 regulatory mutants exhibiting an altered response to CytR. We...

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Identifiers

PMID: 1715855
DOI: 10.1128/jb.173.17.5419-5430.1991
PMCID: PMC208254

Genes

CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The cyclic AMP (cAMP)-cAMP receptor protein complex functions both as an activator and as a corepressor at the tsx-p2 promoter of Escherichia coli K-12.PMID 1715855Read ↗

The CytR repressor antagonizes cyclic AMP-cyclic AMP receptor protein activation of the deoCp2 promoter of Escherichia coli K-12.Semantic proximity Read ↗

Tandem DNA-bound cAMP-CRP complexes are required for transcriptional repression of the deoP2 promoter by the CytR repressor in Escherichia coli.Semantic proximity Read ↗

Identification of the nucleotide sequence recognized by the cAMP-CRP dependent CytR repressor protein in the deoP2 promoter in E. coli.Semantic proximity Read ↗

Transcriptional regulation of the cytR repressor gene of Escherichia coli: autoregulation and positive control by the cAMP/CAP complex.Semantic proximity Read ↗

Protein-protein interactions in gene regulation: the cAMP-CRP complex sets the specificity of a second DNA-binding protein, the CytR repressor.Semantic proximity Read ↗

Mutations that affect transcription and cyclic AMP-CRP regulation of the adenylate cyclase gene (cya) of Salmonella typhimurium.Semantic proximity Read ↗

Dissection of a surface-exposed portion of the cAMP-CRP complex that mediates transcription activation and repression.Semantic proximity Read ↗

Protein-protein communication: structural model of the repression complex formed by CytR and the global regulator CRP.Semantic proximity Read ↗

Crystallization and preliminary X-ray diffraction analysis of D53H mutant Escherichia coli cAMP receptor protein.Semantic proximity Read ↗

A novel function of the cAMP-CRP complex in Escherichia coli: cAMP-CRP functions as an adaptor for the CytR repressor in the deo operon.Semantic proximity Read ↗

Transcriptional control by two interacting regulatory proteins: identification of the PtxS binding site at PtxR.Semantic proximity Read ↗

Allosteric regulation of the cAMP receptor protein.Semantic proximity Read ↗

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