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Article

Transcriptional regulation of the cytR repressor gene of Escherichia coli: autoregulation and positive control by the cAMP/CAP complex.

Molecular microbiology - 1 Mar 1990

Gerlach P, Valentin-Hansen P, Bremer E

Abstract excerpt

The Escherichia coli cytR-encoded repressor protein (CytR) controls the expression of several genes involved in nucleoside and deoxynucleoside uptake and metabolism. The cytR promoter was identified by determining the transcriptional initiation site of the cytR gene. A chromosomal cytR-lacZ+ operon fusion was isolated and used to study the regulation of cytR. We show that cytR expression is negatively controlled...

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Identifiers

PMID: 2162467
DOI: 10.1111/j.1365-2958.1990.tb00614.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Transcriptional regulation of the cytR repressor gene of Escherichia coli: autoregulation and positive control by the cAMP/CAP complex.PMID 2162467Read ↗

Allosteric mechanism of induction of CytR-regulated gene expression. Cytr repressor-cytidine interaction.Semantic proximity Read ↗

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Protein-protein interactions in gene regulation: the cAMP-CRP complex sets the specificity of a second DNA-binding protein, the CytR repressor.Semantic proximity Read ↗

Tandem DNA-bound cAMP-CRP complexes are required for transcriptional repression of the deoP2 promoter by the CytR repressor in Escherichia coli.Semantic proximity Read ↗

A novel function of the cAMP-CRP complex in Escherichia coli: cAMP-CRP functions as an adaptor for the CytR repressor in the deo operon.Semantic proximity Read ↗

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Dissection of a surface-exposed portion of the cAMP-CRP complex that mediates transcription activation and repression.Semantic proximity Read ↗

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