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Article

A basal transcription factor that activates or represses transcription.

Science (New York, N.Y.) - 3 Nov 2000

Willy P J, Kobayashi R, Kadonaga J T

Abstract excerpt

We have identified an activity that is required for transcription of downstream promoter element (DPE)-containing core promoters in vitro. The purified factor was found to be the Drosophila homolog of the transcriptional repressor known as NC2 or Dr1-Drap1. Purified recombinant dNC2 activates DPE-driven promoters and represses TATA-driven promoters. A mutant version of dNC2 can activate DPE promoters but is...

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Identifiers

PMID: 11062130
DOI: 10.1126/science.290.5493.982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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