Multiple levels of response in carcinogenicity bioassays: regulational variation among viable yellow (Avy/-) mice.

Article

Multiple levels of response in carcinogenicity bioassays: regulational variation among viable yellow (Avy/-) mice.

Journal of experimental animal science - 1 Sept 1993

Wolff G L

Abstract excerpt

Within genetically identical inbred and F1 hybrid test animal populations there exist subpopulations with different levels of sensitivity to induction of toxic endpoints, e.g., neoplasms, in response to toxicant exposure. These subpopulations differ from each other by other phenotypic characteris...

Topics

Animals
Animals, Genetically Modified
Drug-Related Side Effects and Adverse Reactions
Female
Gene Expression Regulation
Genetic Variation
Male
Mice
Mice, Mutant Strains
Neoplasms
Phenotype

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