Article
Multiple levels of response in carcinogenicity bioassays: regulational variation among viable yellow (Avy/-) mice.
Journal of experimental animal science - 1 Sept 1993
Wolff G L
Abstract excerpt
Within genetically identical inbred and F1 hybrid test animal populations there exist subpopulations with different levels of sensitivity to induction of toxic endpoints, e.g., neoplasms, in response to toxicant exposure. These subpopulations differ from each other by other phenotypic characteristics as well. Presumably, these differences reflect alterations in the quantitative expression of some genes. These...
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