Controlled genetic variation in a subchronic toxicity assay: susceptibility to induction of bladder hyperplasia in mice by 2-acetylaminofluorene.

doi:10.1080/15287398309530424

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Article

Controlled genetic variation in a subchronic toxicity assay: susceptibility to induction of bladder hyperplasia in mice by 2-acetylaminofluorene.

Journal of toxicology and environmental health - 1 Jan 2000

Wolff G L, Gaylor D W, Frith C H, Suber R L

Abstract excerpt

Five different dose levels of 2-acetylaminofluorene (2-AAF) were fed to weanling mice of 4 different genotypes from three unrelated F1 hybrids for 13 wk to determine differences in susceptibility to induction of bladder hyperplasia. Differences in the prevalence of hyperplasia per se and in the a...

Topics

2-Acetylaminofluorene
Animals
Female
Genotype
Hybridization, Genetic
Hyperplasia
Male
Mice
Sex Factors
Species Specificity
Urinary Bladder Diseases

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