Article
Diabetogenic response to streptozotocin varies among obese yellow and among lean agouti (BALB/c x VY)F1 hybrid mice.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) - 1 Feb 1990
Wolff G L, Greenman D L, Frigeri L G, Morrissey R L, Suber R L, Felton R P
Abstract excerpt
To test the hypothesis that the elevated insulin levels in obese neoplasia-susceptible yellow Avy/- mice might be a major factor stimulating tumor formation, it is necessary to use normoinsulinemic yellow mice. Although our attempt to obtain normoinsulinemic, euglycemic mice by streptozotocin tre...
Topics
- Animals
- Blood Glucose
- Body Weight
- Diabetes Mellitus, Experimental
- Dose-Response Relationship, Drug
- Female
- Genotype
- Insulin
- Islets of Langerhans
- Mice
- Mice, Obese
- Streptozocin