Article
DNA repair and repair fidelity in metastatic variants of the B16 murine melanoma.
Journal of cellular biochemistry - 1 Mar 1993
Usmani B A, Lunec J, Sherbet G V
Abstract excerpt
We have examined the concept of genomic instability in relation to the metastatic progression of low (F1) and high metastasis (BL6, ML8) clones of the B16 mouse melanoma, by using a mutation assay, and DNA strand break repair and repair fidelity assays. The frequency of induced ouabain resistant colonies between the variant cell lines was consistent with the difference between their metastatic properties....
Topics
- Animals
- Bleomycin
- Cell Survival
- DNA Repair
- Ethyl Methanesulfonate
- Melanoma
- Mice
- Models, Genetic
- Mutation
- Reproducibility of Results
- Transfection
- Tumor Cells, Cultured