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Article

High prevalence and heterogeneity of HBV preC mutants in anti-HBe-positive carriers with chronic liver disease in southern Italy.

Journal of hepatology - 1 Jan 1991

Santantonio T, Jung M C, Miska S, Pastore G, Pape G R, Will H

Abstract excerpt

In this study we have investigated the prevalence and type of preC mutants in anti-HBe/HBV-DNA-positive patients with chronic hepatitis B in an endemic area. HBV-DNA from sera of 42 anti-HBe chronic HBV carriers was amplified by PCR and the preC region was directly sequenced. With one exception, all patients tested were found to be infected with viruses containing mutations in the preC region that predictably...

Topics

Base Sequence
Carrier State
DNA, Viral
Genes, Viral
Hepatitis B
Hepatitis B e Antigens
Hepatitis B virus
Humans
Italy
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Prevalence

Source

Identifiers

PMID: 1822518
DOI: 10.1016/0168-8278(91)90030-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1822518-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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