Article
High frequency of the 1896 precore mutation in patients and blood donors with hepatitis B virus infection from the Indian subcontinent.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Jan 2004
Vivekanandan Perumal, Abraham Priya, Sridharan Gopalan, Chandy George, Shaji Ramachandran V, Daniel Dolly, Raghuraman Sukanya, Daniel Hubert Darius, Subramaniam Thenmozhi
Abstract excerpt
AIM: Hepatitis B virus (HBV) e antigen (HBeAg)-negative variants are reported to harbor 1896 precore mutants, and predict a worse clinical outcome. The aim of this study was to estimate the incidence of a precore mutation (1896) in both patients with chronic hepatitis B (CH-B) infection and blood donors in a tertiary care hospital in south India. METHODS: One hundred and twenty-two consecutive HBV DNA-positive...
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