Structural basis for type I and type II deficiencies of antithrombotic plasma protein C: patterns revealed by three-dimensional molecular modelling of mutations of the protease domain.

Abstract excerpt

Familial deficiency of protein C is associated with inherited thrombophilia. To explore how specific missense mutations might cause observed clinical phenotypes, know protein C missense mutations were mapped onto three-dimensional homology models of the protein C protease domain, and the implicat...

Topics

• Amino Acid Sequence
• Binding Sites
• Blood Coagulation Disorders
• Enzyme Activation
• Humans
• Models, Molecular
• Molecular Sequence Data
• Mutation
• Peptide Fragments
• Phenotype
• Proline
• Protein C