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Article

Identification and computationally-based structural interpretation of naturally occurring variants of human protein C.

Human mutation - 1 Apr 2007

Rovida Ermanna, Merati Giuliana, D'Ursi Pasqualina, Zanardelli Sara, Marino Francesca, Fontana Gessica, Castaman Giancarlo, Faioni Elena M

Abstract excerpt

Protein C (PC) is a key regulator of blood clotting and inflammation. Its inherited deficiency is associated with venous thromboembolism, and recombinant activated PC is currently used to increase survival in severe sepsis. The molecular basis of inherited PC deficiency is heterogeneous. Due to its multiple physiologic interactions and functions, and its modular structure, natural variants aid in the...

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Source

Identifiers

PMID: 17152060
DOI: 10.1002/humu.20445

Genes

PROC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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