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Article

Molecular basis of antithrombin deficiency.

Thrombosis and haemostasis - 1 Apr 2011

Luxembourg Beate, Delev Daniel, Geisen Christof, Spannagl Michael, Krause Manuela, Miesbach Wolfgang, Heller Christine, Bergmann Frauke, Schmeink Ursula, Grossmann Ralf, Lindhoff-Last Edelgard, Seifried Erhard, Oldenburg Johannes, Pavlova Anna

Abstract excerpt

Antithrombin (AT) is the most important physiological inhibitor of coagulation proteases. It is activated by glycosaminoglycans such as heparin. Hereditary antithrombin deficiency is a rare disease that is mainly associated with venous thromboembolism. So far, more than 200 different mutations in the antithrombin gene (SERPINC1) have been described. The aim of our study was to characterise the molecular...

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Identifiers

PMID: 21264449
DOI: 10.1160/TH10-08-0538

Genes

SERPINC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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