Phenotypes of Epstein-Barr virus LMP1 deletion mutants indicate transmembrane and amino-terminal cytoplasmic domains necessary for effects in B-lymphoma cells.

Abstract excerpt

The Epstein-Barr virus (EBV) latent infection membrane protein 1 (LMP1) has previously been shown to cause EBV-negative B-lymphoma cells to grow in large clumps and to alter expression of surface activation and adhesion molecules (D. Wang, D. Liebowitz, F. Wang, C. Gregory, A. Rickinson, R. Larso...

Topics

• Amino Acid Sequence
• Antigens, Viral
• Chromosome Deletion
• Fluorescent Antibody Technique
• Herpesvirus 4, Human
• Immunoblotting
• Lymphoma, B-Cell
• Molecular Sequence Data
• Mutation
• Phenotype
• Protein Conformation
• Tumor Cells, Cultured
• Viral Matrix Proteins