Article

Genetic analysis of the role of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) in B cell transformation

2017-01-01

Abstract excerpt

Epstein-Barr virus (EBV) is a gammaherpesvirus that causes infectious mononucleosis and is associated with several human malignancies. In vitro, EBV induces the activation and continuous proliferation of primary human B cells, which carry the viral genome as a latent episome. One of the latency-associated proteins is the EBV nuclear antigen leader protein (EBNA-LP). EBNA-LP is strongly expressed at the initiation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c085f362-1f39-5f3e-ad87-fbc6b0d41e7e
DOI: 10.25560/44554

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of the role of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) in B cell transformationDOI 10.25560/44554Read

Epstein-Barr virus leader protein enhances EBNA-2-mediated transactivation of latent membrane protein 1 expression: a role for the W1W2 repeat domainSemantic proximity Read

Epstein–Barr virus latent genesSemantic proximity Read

The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfoldSemantic proximity Read

The genetic approach to the Epstein-Barr virus: from basic virology to gene therapy.Semantic proximity Read

Conserved regions in the Epstein-Barr virus leader protein define distinct domains required for nuclear localization and transcriptional cooperation with EBNA2.Semantic proximity Read

Epstein- Barr Virus: Clinical and Epidemiological Revisits and Genetic Basis of OncogenesisSemantic proximity Read

Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr VirusSemantic proximity Read

CRISPR/Cas9‐Mediated Genome Editing in Epstein‐Barr Virus‐Transformed Lymphoblastoid B‐Cell LinesSemantic proximity Read

Epstein–Barr Virus B Cell Growth Transformation: The Nuclear EventsSemantic proximity Read

Epstein–Barr Virus: How Its Lytic Phase Contributes to OncogenesisSemantic proximity Read

B-cell lines immortalized with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilization of the oriP-proximal EBNA gene promoter Wp1.Semantic proximity Read

Epstein-Barr virus encoded EBER RNAsSemantic proximity Read