Article
Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas.
Brain pathology (Zurich, Switzerland) - 1 Apr 2002
Hartmann Christian, Johnk Loki, Sasaki Hikaru, Jenkins Robert B, Louis David N
Abstract excerpt
PLA2G4C, encoding cytosolic phospholipase A2-gamma (cPLA2-gamma), is a 17-exon gene located on chromosome 19q13.3 within the putative glioma tumor suppressor gene region. Given the clinical importance of assessing 1p and 19q loss in human gliomas, the development of convenient and practical assays for detecting allelic loss is of considerable priority in neuro-oncology. We report a minisatellite polymorphism in...
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