MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells.

doi:10.1073/pnas.91.12.5523

Article

MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells.

7 Jun 1994

Abstract excerpt

Amplification of the human N-myc protooncogene, MYCN, is frequently seen either in extrachromosomal double minutes or in homogeneously staining regions of aggressively growing neuroblastomas. MYCN maps to chromosome 2 band p23-24, but homogeneously staining regions have never been observed at this band, suggesting transposition of MYCN during amplification. We have employed fluorescence in situ hybridization to...

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