Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells.

7 Jun 1994

Abstract excerpt

Amplification of the human N-myc protooncogene, MYCN, is frequently seen either in extrachromosomal double minutes or in homogeneously staining regions of aggressively growing neuroblastomas. MYCN maps to chromosome 2 band p23-24, but homogeneously staining regions have never been observed at this band, suggesting transposition of MYCN during amplification. We have employed fluorescence in situ hybridization to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Neuroblastoma Research and Treatments
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8202521
DOI: 10.1073/pnas.91.12.5523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells.PMID 8202521Read ↗

Heterogeneity of <i>MYCN</i> amplification in neuroblastoma at diagnosis, treatment, relapse, and metastasisSemantic proximity Read ↗

Ability of Circular Extrachromosomal DNA Molecules to Carry Amplified MYCN Protooncogenes in Human Neuroblastomas In VivoSemantic proximity Read ↗

Excision of N-myc from chromosome 2 in human neuroblastoma cells containing amplified N-myc sequences.Semantic proximity Read ↗

Comparative genetic study of intratumoral heterogenous MYCN amplified neuroblastoma versus aggressive genetic profile neuroblastic tumors.Semantic proximity Read ↗

Amplification of oncogenes in human cancer cellsSemantic proximity Read ↗

Structural organization of MYCN amplicons of neuroblastoma tumors, xenografts, and cell lines characterized by the sequences encompassing the MYCN amplicons in a human neuroblastoma cell line.Semantic proximity Read ↗

Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification.Semantic proximity Read ↗

Characterization at nucleotide resolution of the homogeneously staining region sites of insertion in two cancer cell lines.Semantic proximity Read ↗

The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancersSemantic proximity Read ↗

Altered growth and phenotype in clonal mycN transfectants of the SK-N-SH neuroblastoma cell line.Semantic proximity Read ↗

Double minutes arise from circular extrachromosomal DNA intermediates which integrate into chromosomal sites in human HL-60 leukemia cells.Semantic proximity Read ↗

Augmented MYCN expression advances the malignant phenotype of human neuroblastoma cells: evidence for induction of autocrine growth factor activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.