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Ability of Circular Extrachromosomal DNA Molecules to Carry Amplified MYCN Protooncogenes in Human Neuroblastomas In Vivo

5 Dec 1990

Abstract excerpt

Amplification of the proto-oncogene MYCN (also known as N-myc) in neuroblastomas has been shown to correlate with both disease stage and prognosis, yet little is known about the DNA structures that carry amplified MYCN genes in neuroblastomas in vivo. We have used DNA irradiation and pulsed-field gel electrophoresis to analyze MYCN amplification structures in eight neuroblastomas from separate patients (four...

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PMID: 2250296
DOI: 10.1093/jnci/82.23.1815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ability of Circular Extrachromosomal DNA Molecules to Carry Amplified MYCN Protooncogenes in Human Neuroblastomas In VivoPMID 2250296Read ↗

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Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification.Semantic proximity Read ↗

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Induction of Circles of Heterogeneous Sizes in Carcinogen-Treated Cells: Two-Dimensional Gel Analysis of Circular DNA MoleculesSemantic proximity Read ↗

Identification of MYCN Gene Amplification in Neuroblastoma Using Chromogenic In Situ Hybridization (CISH)Semantic proximity Read ↗

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